Plenary and keynote speakers

Roland W. Frei lecture “Omics technologies and Bioenergetics: application to human disease”
new web_posteProf. Dr. Jan Smeitink
Director of the Institute for Genetic and Metabolic Disease IGMD
Nijmegen/The Netherlands


• Professor in Mitochondrial Medicine and chairperson of the Nijmegen Centre for Mitochondrial Disorders and Head of the Department of Metabolic and Endocrine Disorders of the University Medical Centre Nijmegen.
• Chairman of the Centre for Systems Biology and Bioenergetics and Chief Executive Officer of Khondrion.

His research interests include the study of the mitochondrial OXPHOS system in health and disease with special emphasis on the elucidation of genetic defects underlying complex I. His goals are to enhance the understanding of human mitochondrial complex I assembly, the pathophysiological consequences of mitochondrial disease and the development of new treatment strategies. Novel mass spectrometric tools as such metabolomics play a key role in his cutting edge research.

Plenary lecture "Novel Applications of Ambient Mass Spectrometry"
Prof. Dr. Renato Zenobi
Organic Chemistry Laboratory
Swiss Federal Institute of Technology (ETH)
Zurich, Switzerland
http://www.ethz.ch


Prof. Zenobi is one of the founders and directors of the center of excellence in analytical chemistry (CEAC, 1995 - 2007).
His research areas include laser-based analytical chemistry, electrospray and laser-assisted mass spectrometry, laser-surface interactions, and near-field optical microscopy and spectroscopy. He has made important contributions to the understanding of the ion formation mechanism in matrix-assisted laser desorption/ionization (MALDI) mass spectrometry, to ambient ionization methods, and to the development of analytical tools for nanoscale applications.

Plenary lecture"Metabolomics: Opportunities for Personalized Medicine & Pharma"
Prof. Dr. Thomas Hankemeier
Head of Division Analytical Biosciences
Leiden Amsterdam Center for Drug Research, Leiden University
Scientific Director of Netherlands Metabolomic Centre
NL-2333 CC Leiden
E-mail: hankemeier@lacdr.leidenuniv.nl


His research is aiming at innovative analytical tools for metabolomics-driven systems biology in personalized health strategies. His research aims at improving multi-dimensional separation methods, improving the interfacing to mass spectrometry, miniaturizing sampling devices and separation systems using micro/nano-technology and developing methods for the identification of metabolites. In collaboration with clinicians, biomedical researchers, biostatisticians and other –omics researchers he works on better (early) diagnosis and interventions for cardiovascular disease, diabetes and neurological diseases. As he is convinced that important progress can only be realized in combining expertise in multidisciplinary projects and strategic alliances, he is initiator and scientific director of the Netherlands Metabolomics Centre.

Plenary lecture "Novel biomarker profiling approaches in human sport doping control"
Prof. Dr. rer nat. et phil. nat. Patrick Rene Diel is head of the work group Molecular Endocrinology, at the Dept. Mol. Cel. Sportsmedicine of the German Sports University Cologne, Germany

Heading WADA funded projects for the development of biomarker based antidoping assays.
Prof. Diel is coordinator of the DFG funded research cluster : “Isoflavones: Cross-species’ comparison on metabolism, estrogen sensitivity, epigenetics and carcinogenesis”. He is directing the Sino-German cooperation project: The impact of dietary phytoestrogen on the reproductive/endocrine system’s development and managing WADA funded projects for the development of biomarker based antidoping assays.

Keynote lecture“Information management of complex metabolic profiles in population screening and individualized medicine”
Prof. Piero Rinaldo, Co-director, Biochemical Genetics, Laborary Mayo Clinic, College of Medecine Rochester, Minnesota (USA);
Professor of Laboratory Medicine, T. Denny Sanford, Professor of Pediatrics and Vice-chair, Department of Laboratory Medicine and Pathology


His past research interests include the development and validation of tandem mass spectrometry methods in clinical laboratory practice and the biochemical characterization of metabolic disorders, with special focus on mitochondrial fatty acid oxidation disorders. His current primary focus is the expansion and quality improvement of newborn screening for metabolic disorders through a collaborative effort involving 157 laboratories in 57 countries.

Keynote lecture"Metabolic Networks and Inborn Errors of Metabolism - From Garrod to Metabolomics"

Dr. Brian Fowler, recently retired as Head of Labs and Biochemist at the University Children's Hospital Basel, Switzerland

He has a long-standing interest in inherited metabolic disease, specialising in disorders of homocysteine and related vitamin metabolism. He was born in Manchester, England in 1946 where he studied biochemistry. He attained the degree of Ph.D. at the Dept. of Medical Biochemistry, University of Manchester in 1972. Postdoctoral studies at the Royal Manchester Children's Hospital were followed by a period as Research Associate at Yale University. In 1976 he returned to the Royal Manchester Children's Hospital as Head of the laboratory section of the Willink Biochemical Genetics Unit until 1990 when he moved to take up his present post. Between 1988 and 1999 he was honoured to be first, Honorary Secretary and then Chairman of the Society for the Study of Inborn Errors of Metabolism. From 1999 to 2008 he has undertaken the role of Chairman of ERNDIM, the European network for quality control in inherited metabolic disorders and is currently President of the Swiss National Society for Inherited metabolic disorders.
He currently represents ERNDIM within the EUGT2 project.
After retirement he will continue his research interest based in the Children's Hospital Zürich and ERNDIM and EUGT activities from Basel.

Keynote lecture"Quantitation of Biomarkers for Growth Hormone Abuse in Dried Blood Spots"

Dr. Holly D. Cox
Sports Medicine Research and Testing Laboratory SMRTL
Salt Lake City, USA


Her work focuses on the development of dried blood spot methods for detection of prohibited substances in anti-doping and the development of mass spectrometry methods to detect abuse of protein and peptide hormones.

She is a collaborating member of the IGF-1 Working Group organized by the U.S. Anti-Doping Agency (USADA) to develop a mass spectrometry method to measure IGF-1 in serum for detection of growth hormone abuse.

Keynote lecture Title
Dr. Steven Gross
Professor of Pharmacology and Director of the Mass Spectrometry Facility,
Weill Cornell Medical College, New York, NY USA


His major research interest over the past two decades has been elucidating mechanisms of cell signaling by reactive molecules, with a primary focus on the physiological chemistry and biology of nitric oxide (NO).  Work on NO has culminated in over 25 issued US patents and co-founding of a biotech start-up that conducted a multinational phase III clinical study to test the therapeutic efficacy of a NOS inhibitor for a life-saving cardiovascular indication.  Since reactive molecules typically mediate their cell signaling actions by engaging in covalent reactions with proteins, he worked to develop proteomic approaches that can be used to define and inventory various NO-mediated protein modifications.  These efforts led to an interest inbiological mass spectrometry (MS) and his establishment in 1997 of the MS core facility at Weill Cornell Medical College.  As Director of the MS core facility, he acquired experience and know-how in the use of bioanalytical techniques for high-throughput protein and small molecule analyses.  This includes establishment of an MS-based platform for broad untargeted profiling of structurally-diverse small molecules (50 – 1000 Da) to discover the metabolic consequence of gene mutations, disease processes and drug treatments. Applications of this metabolite profiling approach will be the focus of his LC/MS talk.

Keynote lecture "Identification of Unknowns using Mass Spectral Library Cloud"
Dr. Robert Mistrik
HighChem, Bratislava, Slovakia


Dr. Mistrik is the creator of Mass Frontier, software for processing and interpreting mass spectral data in which the spectral tree concept was introduced. He is author of precursor ion fingerprinting method that allows identification of unknown compounds based on substructural identities of tandem mass spectra. He has been a member of the scientific steering committee of the METAcancer consortium, aiming to identify small molecule biomarkers in breast cancer tissue. Currently, he is leading the m/z Cloud initiative that is a collaborative effort to build a comprehensive spectral trees library for identification of metabolic components utilizing molecular evolutionary patterns. Robert Mistrik has been recently elected as a director of the Metabolomics Society.

Keynote lecture "Genetics meets Metabolomics: Inborn Variations in Human Metabolism"
Dr. Gabi Kastenmüller
Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt, GmbH
D-85764 Neuherberg
Email: g.kastenmueller@helmholtz-muenchen.de

Her research is centered around the analysis and interpretation of high-throughput metabolomics and genomics data sets by the means of bioinformatics and systems biology. In particular, she is interested in genetically induced metabolic individuality in the human population and in how this individuality affects the development and progression of complex diseases. Methodologically, she aims at developing novel approaches for interpreting metabolomics data in the context of biochemical pathways, for identifying unknown metabolites, and for integrating metabolomics data from various platforms.
After joining Karsten Suhreís lab in 2009, she was involved in the first large-scale studies on metabolic individuality. Since 2011, she is heading the Metabolomics group within the Institute of Bioinformatics and Systems Biology at the Helmholtz Center Munich.

Keynote lecture "LC/MS today: From Applications for the Expert to Those for the ‘Masses"
Jack Henion
Professor Emeritus
Analytical Toxicology
New York State College of Veterinary Medecine
Cornell University
927 Warren Dr.
Ithaca, NY 14850
Cell: 607 279 9043
E-mail: jdh4@cornell.edu


Jack Henion is Professor Emeritus at Cornell University in the Analytical Toxicology Section of the Diagnostic Laboratory within the College of Veterinary Medicine. He is also a co-founder, Chairman and CSO of Advion BioSciences (ABS), Inc., located in Ithaca, New York. Advion is a premier contract service laboratory specializing in LC/MS/MS analyses for the pharmaceutical and agrochemical industries. Avdion has developed proprietary chip-based nanoelectrospray devices that may be used in future ‘Lab-on-a-Chip’ strategies for LC/MS analyses. Dr. Henion’s work in LC/MS relates to the analysis of real-world samples common to pharmaceutical, environmental, and biochemical problems. The instructor has published extensively in the areas of conventional capillary GC/MS as well as LC/MS, SFC/MS, IC/MS, and CE/MS using atmospheric pressure ionization (API) technologies with quadrupole, ion trap, and time-of-flight mass spectrometers.

Keynote lecture "Current Trends in Clean-up of Biofluids for LC-MS/MS Analysis of Small Molecules"
Prof. Dr. Dr. Karl-Siegfried Boos
Laboratory of BioSeparation
Institute of Laboratory Medicine LMU
Munich, Germany
Email: boos@med.uni-muenchen.de


Karl-Siegfried Boos is author and co-author of over 100 original publications in the fields of Biochemistry, Analytical Chemistry and Medicine. He has been invited to numerous national and international meetings as plenary or keynote lecturer as well as to present tutorials and short courses.
From 1974 till 1984 his research interest centered on the synthesis and investigation of modified nucleotides as molecular probes in energy transducing biosystems (membrane transport and oxidative phosphorylation in mitochondria; photophosphorylation in chloroplasts). Since 1985 his research activities have been directed to the synthesis and application of chemically and enzymatically modified stationary phases (Restricted Access Materials, RAM; Moleculary Imprinted Polymers, MIP) for HPLC-integrated, i.e. on-line sample processing and analysis of marker molecules in biological fluids (Therapeutic Drug Monitoring, Biological Monitoring). Currently, his research focus is on the development of fully automated, multidimensional separation and detection methods as well as platforms (e.g. SPE-LC-MS/MS) for bioanalysis and on the standardization and integration of preanalytics Since 1990,when he established the Laboratory of BioSeparation at the Institute of Clinical Chemistry, Medical Center of the University of Munich, his interest also is on the design, synthesis and application of biocompatible adsorbents for the selective gastrointestinal as well as extracorporeal elimination of harmful compounds in humans by peroral dosage (e.g. dialysis patients) and on-line adsorption apheresis of blood plasma (e.g. septic patients), respectively.

Keynote lecture "Deep Phenotyping of Cellular Metabolism by High Throughput, Accurate Mass Metabolomics"
Dr. Nicola Zamboni
ETH Zurich
Institute of Molecular Systems Biology
Zurich, Switzerland
E-Mail: zamboni@imsb.biol.ethz.ch


His research is devoted to the investigation of cellular metabolism, from microorganisms to human lines. The largely relies on high-throughput metabolomics, 13C metabolic flux analysis, fluorescence microscopy, and mathematical modelling to unravel molecular mechanisms governing metabolic phenotypes.

Keynote lecture "The role of LC-MS in the Automated Clinical Laboratory"
Prof. Dr. sc.nat. Katharina Rentsch
Universitätsspital Basel
Labormedizin
Klinische Chemie
Basel, Switzerland
E-Mail: rentschk@uhbs.ch


Katharina Rentsch is a Clinical Chemist using LC-MS techniques for research purposes and routine applications since the instruments started to come into the clinical laboratories. Her research focus is the development of analytical methods for the quantification of drugs in the context of therapeutic drug monitoring or for the identification of unknown drugs in intoxicated patients. In recent years she was also involved in a 7th framework programme project of the European Union searching new lipid biomarkers.

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